Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche
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چکیده
منابع مشابه
The hematopoietic stem cell niche in homeostasis and disease.
The bone marrow microenvironment contains a heterogeneous population of stromal cells organized into niches that support hematopoietic stem cells (HSCs) and other lineage-committed hematopoietic progenitors. The stem cell niche generates signals that regulate HSC self-renewal, quiescence, and differentiation. Here, we review recent studies that highlight the heterogeneity of the stromal cells t...
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The hematopoietic system requires constant replenishment of its end products, a large and heterogeneous array of terminally differentiated cells and corpuscles, which are essential for oxygenation, clotting, and immunity. Because this daily requirement continues throughout the life of an individual, hematopoietic stem cells (HSCs), the cells at the apex of this well-orchestrated hierarchy, requ...
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The stem cell microenvironment is involved in regulating the fate of the stem cell with respect to self-renewal, quiescence, and differentiation. Mathematical models are helpful in understanding how key pathways regulate the dynamics of stem cell maintenance and homeostasis. This tight regulation and maintenance of stem cell number is thought to break down during carcinogenesis. As a result, th...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2019
ISSN: 1934-5909
DOI: 10.1016/j.stem.2018.11.013